D- proline amide
H-D-Pro-NH2
CAS: 62937-45-5
Molecular Formula: C5H10N2O
D- proline amide - Names and Identifiers
| Name | H-D-Pro-NH2 |
| Synonyms | H-D-Pro-NH2 H-D-PRO-NH2 D-Prolinamide (R)-PROLINAMIDE (R)-Prolinamide D- proline amide D-(-)-Prolinamide H-D-ProNH2, free base D-Prolinamide free base (R)-PYRROLIDINE-2-CARBOXAMIDE (2S)-Pyrrolidine-2-carboxamide 2-Pyrrolidinecarboxamide,(2R)-(9CI) (R)-PYRROLIDINE-2-CARBOXYLIC ACID AMIDE |
| CAS | 62937-45-5 |
| EINECS | 613-116-7 |
| InChI | InChI=1/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)/t4-/m1/s1 |
D- proline amide - Physico-chemical Properties
| Molecular Formula | C5H10N2O |
| Molar Mass | 114.15 |
| Density | 1.106±0.06 g/cm3(Predicted) |
| Melting Point | 95-97°C |
| Boling Point | 303.6±31.0 °C(Predicted) |
| Flash Point | 137.4°C |
| Water Solubility | Soluble in water. |
| Solubility | DMSO, Ethanol |
| Vapor Presure | 0.000923mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | Off-White |
| BRN | 471499 |
| pKa | 16.21±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.491 |
| MDL | MFCD00153457 |
D- proline amide - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29339900 |
D- proline amide - Reference Information
| Introduction | D-prolinamide has a melting point of 95 degrees to 97 degrees and a density of 1.1, the appearance was white to gray-white solid powder at normal temperature and pressure. D-prolinamide is soluble in dimethyl sulfoxide, N,N-dimethylformamide, methanol, ethanol and other organic solvents, in addition, the compound also has a certain solubility in water. It is a common intermediate in chiral organic synthesis. |
| Use | D-prolinamide as a common intermediate in organic synthesis, the primary use is in the synthesis of catalyst molecules or chiral drug molecules as molecular backbones. In organic synthesis, the amide group in D-prolinamide can be reduced to a first-order amine compound by lithium aluminum tetrahydrate. In the synthesis of metal-organic compounds, D-prolinamide can be obtained by reacting with zinc bromide or zinc chloride, and one zinc atom binds two metal complexes of D-prolinamide. |
| synthesis method | D-prolinamide can be derived from its corresponding D-proline, first, the carboxylic acid group is subjected to a one-step chlorination to change the carboxylic acid into an acid chloride, and then the acid chloride is converted into an amide. |
| Environmental hazard | as an organic amine, D-prolinamide is slightly harmful to water environment, undiluted or bulk products should not be exposed to groundwater, watercourses or sewage systems. |
Last Update：2024-04-09 21:54:55
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